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  • Poor chemical and microbiological quality of the ...

    2019-7-31u2002·u2002Introduction. It has been reported that approximately 20% to 50% of European and US adults use herbal-based dietary supplements 1, further that this trend is steadily increasing, with billions of dollars spent annually on herbal-based dietary supplements 2.The extract of milk thistle, Silybum marianum, is among the most common and one of the six best-selling herbal-based …

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  • Silymarin as Supportive Treatment in Liver Diseases: A ...

    2020-2-17u2002·u2002Silymarin was first isolated in 1968 by German scientists at the University of Munich and then described and patented by the German herbal medicine manufacturer Madaus as a specific treatment 'against liver diseases' [].The first commercial preparation of silymarin was developed by Rottapharm/Madaus (Cologne, Germany) and complies with the analytical …

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  • Silybum marianum - American Botanical Council

    Silybum marianum (milk thistle), administered in combination with Withania somnifera and Trigonella foenum-graecum, exhibited a protective effect against myofibrillary protein breakdown of myosin heavy chain-II degradation in C2C12 myotubules by stimulating Akt-dependent protein synthesis and p38 MAPK/myogenin-dependent myoblast differentiation.

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  • (PDF) Evaluation of the Immunomodulatory Effects of ...

    2021-12-24u2002·u2002The greatest scolicidal effects were obtained with the combination of S. marianum with albendazole (79%), S. marianum ethanolic extract alone (77%) and albendazole (69%), at a concentration of 500 ...

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  • Silybum marianum ethanolic extract: in vitro effects on ...

    2021-9-8u2002·u2002Cystic echinococcosis (CE), is a parasitic zoonosis caused by Echinococcus granulosus (E. granulosus) larvae in liver and lungs of both humans and animals. Surgical intervention is the mainstay for CE treatment, using scolicidal agents that inactivate live protoscolices. This study evaluated the scolicidal effects of Silybum marianum ethanolic extract and its combination with …

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  • Silymarin: A review of pharmacological aspects and ...

    Silymarin is obtained from Silybum marianum (milk thistle), an edible plant that has been used medicinally for centuries as a herbal medicine for the treatment of liver-related disorders. It is widely prescribed by herbalists and has almost no known side effects. The plant is native to the Mediterranean and grows throughout Europe and North America.

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  • (PDF) Reassessing Bioavailability of Silymarin

    Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling ...

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  • Poor chemical and microbiological quality of the ...

    2019-7-31u2002·u2002Herbal-based dietary supplements have become increasingly popular. The extract from milk thistle (Silybum marianum), is often used for the …

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  • The chemopreventive effect of Ginkgo biloba and Silybum ...

    2011-10-31u2002·u2002This study was designed to evaluate the potential chemopreventive activities of Ginkgo biloba extract (EGb) and Silybum marianum extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (NDEA) in rats. Rats were divided into 6 groups. Group 1 served as normal control rats. Group 2 animals were intragastrically administrated NDEA at a dose of 10 …

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